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KMID : 0370219960400060690
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Yakhak Hoeji
1996 Volume.40 No. 6 p.690 ~ p.696
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Differentiation Effect of Marine Natural Compounds on F9 Teratocarcinoma Stem Cells
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김리라/Kim LL
백진현/조용진/손병화/최홍대/김규원/Baek JH/Cho YJ/Son BW/Choi HD/Kim KW
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Abstract
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It has been known that many kinds of cancer are caused by continued proliferation or abnormal differentiation. Thus, recent approaches to anticancer therapy have been focused on developing drugs that induce differentiation of cancer cells to normal cells. A typical differentiation agent, all trans-retinoic acid, is unsuitable for anticancer drug because all trans-retinoic acid produces unfavorable side effects and cytotoxicity in normal cells. Therefore, we have screened some new differentiation-inducing compounds obtained from marine organisms using F9 teratocarcinoma stem cells as a model system. We observed that fatty acid. glycolipid, saponin, sphingosine and sterol compounds of marine organisms had differentiation-inducing activity in F9 cells, were determined by morphological changes and Northern blot analysis. The expression of differentiation marker genes, such as laminin B1, type IV collagen and retinoic acid receptor beta were induced by treatment with those compounds.
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KEYWORD
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